Tuesday, June 16

Extracorporeal Membrane Oxygenation in the Interstage Period After Norwood and Related Stage I Palliations in Infants With Single Ventricle: A Systematic Review of Incidence, Risk Factors, and Outcomes.

Extracorporeal Membrane Oxygenation in the Interstage Period After Norwood and Related Stage I Palliations in Infants With Single Ventricle: A Systematic Review of Incidence, Risk Factors, and Outcomes.: New evidence identified. See linked sources for details.

Significant heterogeneity across studies precluded meta-analysis, highlighting the need for standardized reporting in future research.

Relevance: Directly addresses HLHS (Norwood procedure) and Fontan circulation in neonates with single ventricle. Discusses post-operative management including ECMO support, myocardial dysfunction, and interstage outcomes. Highly relevant to profile diagnoses (dx-hlhs, dx-fontan) and research interests (single ventricle outcomes, Fontan circulation).

Model-informed dose optimization of carvedilol and nebivolol in cirrhotic patients: a pilot randomized clinical study.

Model-informed dose optimization of carvedilol and nebivolol in cirrhotic patients: a pilot randomized clinical study.: New evidence identified. See linked sources for details.

PBPK-guided dosing addressed pharmacokinetic changes, but pharmacodynamic differences between CP-A and CP-B persisted due to disease progression.

Relevance: Pharmacokinetic study of carvedilol and nebivolol dosing in cirrhotic adults with hypertension. Carvedilol is in the profile formulary. While this is adult-focused and addresses liver disease rather than profile diagnoses, beta-blocker pharmacology data informs pediatric practice and the findings are relevant to understanding carvedilol use.

Trial Status Change: Clinical Study of Atorvastatin in the Treatment of Acute Kawasaki Disease Complicated With Coronary Artery Abnormalities in Children

Trial Status Change: Clinical Study of Atorvastatin in the Treatment of Acute Kawasaki Disease Complicated With Coronary Artery Abnormalities in Children: New evidence identified. See linked sources for details.

Relevance: This trial directly addresses treatment of acute Kawasaki disease (dx-kawasaki) with coronary artery abnormalities in children. Kawasaki disease management is a core diagnosis in the profile, and this pediatric study examining atorvastatin therapy for Kawasaki disease complications is directly relevant to the practice's clinical focus, even though atorvastatin is not on the current formulary.