Literature
In-hospital mortality predictors of heart failure patients 80 years and older: An observational retrospective single-center experience.
Signal observed that in-hospital mortality among elderly heart failure patients (≥80 years) reaches 20.1%, with several laboratory markers serving as predictors. Evidence suggests that elevated white blood cell count (≥9.75 × 10⁹/L), creatinine (≥1.75 mg/dL), and C-reactive protein (≥28.45 mg/L), along with hyponatremia and hypoalbuminemia, correlate with increased mortality risk. Worth noting that systolic heart failure and ischemic etiology were more prevalent in non-survivors compared to survivors.
Large prospective trials should be conducted to describe the causative relationship between these predictive factors and in-hospital outcomes in elderly HF patients.
Relevance: While this addresses heart failure outcomes (a profile research interest), the geriatric population and mortality predictors are not directly applicable to pediatric cardiology practice.
PMID: 41931326Medicine(Journal Article) Literature
Peripartum cardiomyopathy presenting during caesarean section.
Signal observed of peripartum cardiomyopathy presenting as acute heart failure with left ventricular ejection fraction of 35-40% during cesarean delivery. Evidence suggests that concurrent pulmonary embolism can complicate the clinical picture, requiring staged escalation to therapeutic anticoagulation once hemostasis is secured. Worth noting the successful implementation of guideline-directed heart failure therapy with multidisciplinary management leading to clinical improvement.
This case highlights the need to consider peripartum cardiomyopathy in postpartum collapse despite an identified pulmonary embolus and emphasises early echocardiography, biomarkers and multidisciplinary management.
Relevance: Though related to heart failure management and anticoagulation (matching profile interests), this adult peripartum context is not directly relevant to pediatric cardiology practice.
PMID: 41881478BMJ case reports(Journal Article) Literature
Efficacy and safety of sacubitril/valsartan in patients on peritoneal dialysis: a systematic review and meta-analysis.
Signal observed that sacubitril/valsartan demonstrates efficacy in peritoneal dialysis patients with heart failure, showing significant LVEF improvement (mean difference 5.22%) and NT-proBNP reduction. Evidence suggests the medication reduces systolic blood pressure by approximately 14.6 mmHg while maintaining an acceptable safety profile. Worth noting that hyperkalemia incidence increased modestly to 11.94%, while hypotension and angioedema remained rare events.
These findings suggest potential benefit in this understudied population, though confirmation in adequately powered RCTs remains necessary.
Relevance: While addressing heart failure management (a profile research interest), this focuses on adult renal disease patients rather than pediatric populations with congenital heart disease.
PMID: 41931676Jornal brasileiro de nefrologia(Journal Article)