Literature
Overview of findings from the UK and Ireland National Advanced Heart Failure Audit 2024.
Signal observed of significant regional variation in referral rates for heart transplantation and LVAD therapy across the UK and Ireland, with approximately 100 referrals per month for advanced heart failure interventions. Evidence suggests potential inequity in access to these therapies, with women comprising only one-third of patients assessed for advanced heart failure treatments. Worth noting that distance to transplant centers and deprivation levels did not influence referral patterns, indicating clinician awareness or local referral culture as potential drivers of variation.
Further work is required to investigate barriers to referral, enhance clinician awareness and optimise care pathways for patients in need of both life-prolonging and supportive...
Relevance: UK audit of advanced heart failure referral patterns for transplantation and LVAD therapy in adults. Related to heart failure management (research interest) but focuses on adult referral pathways and inequity in access rather than pediatric-specific disease management or outcomes.
PMID: 42229998Open heart(Journal Article) Literature
Prolonged ventricular fibrillation treated with nifekalant in fulminant myocarditis following late-onset coronavirus disease 2019.
Signal observed of successful treatment of refractory ventricular fibrillation with nifekalant in a late-teens patient with COVID-19-associated fulminant myocarditis. Evidence suggests nifekalant terminated persistent VF lasting five days when amiodarone and repeated defibrillation failed, while the patient was supported with extracorporeal membrane oxygenation and Impella. Worth noting the endomyocardial biopsy confirmed CD68 macrophage-predominant inflammation consistent with COVID-19-associated myocarditis.
Endomyocardial biopsy demonstrated CD68 macrophage-predominant inflammation, consistent with COVID-19-associated myocarditis.This case suggests that nifekalant may be a valuable therapeutic option for managing life-threatening ventricular arrhythmias...
Relevance: Case report of fulminant myocarditis with ventricular fibrillation following COVID-19 treated with nifekalant. Related to acute cardiac dysfunction and arrhythmia management but addresses post-viral myocarditis in an adolescent, not the specific congenital conditions in the profile.
PMID: 42191227BMJ case reports(Journal Article) Literature
Incidence and predictors of major arrhythmic events after myocarditis: a systematic review and meta-analysis.
Evidence suggests 28% of patients with complicated myocarditis experience major arrhythmic events during follow-up, with a median time to presentation of 12 months in this meta-analysis of 3,954 patients. Signal observed that high-grade atrioventricular block, major arrhythmic events at presentation, and fulminant myocarditis were associated with higher risk of future arrhythmic events. Worth noting the composite incidence included sustained ventricular tachycardia (22%), appropriate ICD/WCD interventions (20%), and aborted cardiac arrest/ventricular fibrillation (6%).
Further prospective studies are needed to better stratify high-risk patients, identify those with an underlying arrhythmogenic cardiomyopathy, and guide antiarrhythmic strategies.
Relevance: Meta-analysis of major arrhythmic events after myocarditis with predictors identified. Related to cardiac arrhythmia risk and myocarditis but primarily addresses adult acute myocarditis outcomes rather than congenital conditions and chronic arrhythmia management in pediatric populations.
PMID: 42175819Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology(Journal Article) Literature
Effective Transcatheter Mitral Valve Repair for Reverse Remodeling in Cancer Therapy-Related Cardiac Dysfunction.
Signal observed of successful transcatheter edge-to-edge mitral valve repair leading to dramatic improvement in cancer therapy-related cardiac dysfunction, with left ventricular ejection fraction recovering from 26% to 61% at 12 months. Evidence suggests the patient had severe heart failure following anthracycline and anti-HER2 therapy, with cardiac MRI and biopsy showing interstitial fibrosis and myofibrillary degeneration. Worth noting that TEER provided hemodynamic stabilization and enabled reverse remodeling in this case of chemotherapy-induced cardiomyopathy.
We report a valuable case of CTRCD in which TEER was effective for reverse remodeling by comparing imaging and pathological evaluations.
Relevance: Case report of transcatheter mitral valve repair for cancer therapy-related cardiomyopathy demonstrating reverse remodeling. Related to heart failure (research interest) and cardiac intervention, but addresses adult cancer-induced dysfunction rather than congenital or pediatric cardiac conditions in the profile.
PMID: 42219332International heart journal(Journal Article)