Admission blood pressure percentiles and in-hospital mortality in pediatric heart failure: a multicenter retrospective cohort study.
Evidence suggests admission blood pressure percentiles demonstrate U-shaped and linear associations with in-hospital mortality in pediatric heart failure, with a multicenter study of 2,545 children identifying optimal systolic BP range at 57th-91st percentiles and diastolic BP threshold above 83rd percentile for lowest mortality risk. Worth noting that sex-stratified analyses revealed girls may be more vulnerable to elevated systolic pressures while boys showed greater susceptibility to low diastolic pressures, with consistency observed across major diagnostic categories including congenital heart disease etiologies. Signal observed for age-differential effects, with the blood pressure-mortality relationship primarily driven by infants and toddlers in this cohort.
This study establishes novel BP percentile thresholds for mortality risk stratification in patients with PHF (SBP: 57th-91st; DBP: 83rd-100th) and provides preliminary evidences for sex-...
Relevance: Directly addresses pediatric heart failure outcomes with risk stratification data applicable to congenital heart disease populations including HLHS and Fontan patients, aligning with research interests in heart failure and single ventricle outcomes.