Literature
Concomitant Tricuspid Valve Surgery During HeartMate 3 LVAD Implantation and Long-Term Outcomes: Insights From the ELEVATE Registry.
Evidence suggests that concomitant tricuspid valve surgery during HeartMate 3 LVAD implantation does not affect 5-year survival but may reduce right heart failure risk (0.038 vs 0.092 events per patient-year, P=0.03). Signal observed from ELEVATE registry analysis of 463 patients showing no differences in survival, functional capacity, or end-organ function between matched cohorts with and without tricuspid intervention. Worth noting that these findings on mechanical support and right heart function may inform approaches to single ventricle patients with Fontan circulation who develop heart failure.
NCT02497950.
Relevance: Analysis from ELEVATE registry of tricuspid valve surgery during HeartMate 3 LVAD implantation outcomes. Directly relevant to heart failure management (research interest) and single ventricle/advanced heart failure outcomes. While adult population, findings on mechanical support and right heart function inform pediatric practice for Fontan and single ventricle patients.
PMID: 41871602European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery(Journal Article) Literature
Dynamic association between triglyceride-glucose-body mass index and hospital mortality in critically ill patients with heart failure: a multicenter retrospective cohort study.
Evidence suggests a reproducible U-shaped association between triglyceride-glucose-BMI (TYG-BMI) and hospital mortality in critically ill heart failure patients across three large databases (n=5,133, pooled mortality 27.9%). Signal observed that optimal TYG-BMI range of 250-275 was associated with reduced mortality risk (OR=0.76, 95% CI 0.68-0.85), while values >425 showed progressively increased mortality. Worth noting that combining TYG-BMI with SOFA score significantly improved discriminative performance beyond SOFA alone (AUC: 0.780 versus 0.720).
Both intensity and exposure duration contribute to risk stratification, though prospective validation is warranted given the observational design and uncertain physiological specificity of TYG-BMI in...
Relevance: Multicenter retrospective study examining association between metabolic markers and hospital mortality in critically ill heart failure patients. Directly addresses heart failure outcomes (research interest), includes analysis of multiple ICU databases relevant to pediatric critical care, though population includes adults. Findings may inform pediatric HF management.
PMID: 41877141Cardiovascular diabetology(Journal Article) Literature
Women's IschemiA TRial to Reduce Events In Non-ObstRuctive CAD (WARRIOR): a randomised controlled trial.
Evidence suggests that intensive medical treatment with high-intensity statin, ACE inhibitor/ARB, and aspirin did not reduce major adverse cardiovascular events compared to usual care in 2,476 women with suspected non-obstructive coronary disease (HR=1.13, 95% CI 0.94-1.37, p=0.20). Signal observed that hospitalizations for angina were the dominant contributor to outcomes at 2.5 years follow-up. Worth noting the trial was underpowered due to lower than planned recruitment and a population with well-controlled baseline risk factors.
NCT03417388.
Relevance: Randomized trial (WARRIOR) of intensive medical treatment including ACE inhibitors and aspirin in women with suspected non-obstructive coronary disease. While ACE inhibitors (enalapril) and aspirin are in the formulary, this adult coronary disease trial is not directly relevant to the profile's congenital heart disease diagnoses or single ventricle management.
PMID: 41932694Open heart(Journal Article) Literature
A systematic review of the relationship between race and health-related quality of life outcomes in patients with advanced heart failure who undergo heart transplantation or mechanical circulatory support.
Evidence suggests racial differences in health-related quality of life may exist among adults undergoing heart transplantation or mechanical circulatory support, with Black patients experiencing less HRQOL improvement with MCS compared to White patients. Signal observed across eight studies (mean age 57 years, 80% White, 78% male) that race did not impact HRQOL in 50% of heart transplant studies. Worth noting that HRQOL measures were not comparable across studies, limiting meta-analysis capability and requiring more research in this area.
Racial differences in HRQOL may exist among adults who undergo HT and/or MCS; more research is needed.
Relevance: Systematic review of health-related quality of life in adult patients undergoing heart transplantation or mechanical circulatory support. While addresses advanced heart failure therapies that may be relevant to Fontan/single ventricle outcomes research interest, focuses on adult population, not pediatric congenital heart disease.
PMID: 41920216Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation(Journal Article) Literature
Residual left atrial v wave predicts clinical outcome of transcatheter edge-to-edge mitral valve repair.
Evidence suggests that residual left atrial v wave pressure below 25 mmHg after transcatheter mitral valve repair strongly predicts favorable outcomes regardless of echocardiographic mitral regurgitation grade. Signal observed in 299 patients that post-procedure LA v wave pressure was an independent predictor of death or heart failure hospitalization (HR 1.29 per 10 mmHg, 95% CI 1.06-1.57, p=0.012). Worth noting that intraprocedural LA pressure monitoring provided incremental prognostic information beyond standard echocardiographic assessment of residual regurgitation.
LAvP after device implantation provides incremental prognostic information beyond echocardiographic MR grading and may therefore assist intraprocedural decision-making during M-TEER.
Relevance: Study of left atrial pressure changes predicting outcomes after mitral valve repair (M-TEER). Addresses valve disease and heart failure outcomes relevant to profile research interests. While adult procedure, hemodynamic principles may inform pediatric valve disease management, though not specific to congenital diagnoses.
PMID: 41869902ESC heart failure(Journal Article)