Literature
Learning from a pitfall: Atrial septostomy in LV failure under VA-ECMO for pulmonary hypertension.
Learning from a pitfall: Atrial septostomy in LV failure under VA-ECMO for pulmonary hypertension.: New evidence identified. See linked sources for details.
The implications of atrial septostomy should be carefully considered prior to decompression, as there may be situations, especially if right-sided pressures are less than left-sided...
Relevance: Case report of atrial septostomy in a patient with pulmonary hypertension and VA-ECMO. Directly relevant to profile research interests in pulmonary hypertension management and single ventricle/Fontan-type hemodynamics (atrial septostomy is used in similar complex cardiac conditions). Addresses interventional management of PH complications.
PMID: 42319106The journal of extra-corporeal technology(Case Reports) Literature
Cardioprotective role of antihypertensive treatment in chemotherapy-induced cardiotoxicity: umbrella review of meta-analyses of randomised controlled trials.
Cardioprotective role of antihypertensive treatment in chemotherapy-induced cardiotoxicity: umbrella review of meta-analyses of randomised controlled trials.: New evidence identified. See linked sources for details.
CRD420251046471.
Relevance: Umbrella review of ACE inhibitors and beta-blockers for chemotherapy-induced cardiotoxicity prevention. Enalapril (ACE inhibitor) and carvedilol (beta-blocker) are in the profile formulary. While the clinical context (cancer therapy) differs from profile diagnoses, the pharmacology of these cardiac medications is directly relevant and findings inform pediatric use.
PMID: 42315195Open heart(Journal Article) Literature
Beta-Blockers After Myocardial Infarction With Preserved and Mildly Reduced Ejection Fraction: A Meta-Analysis With Trial Sequential Analysis.
Beta-Blockers After Myocardial Infarction With Preserved and Mildly Reduced Ejection Fraction: A Meta-Analysis With Trial Sequential Analysis.: New evidence identified. See linked sources for details.
β-blockers conferred no benefit in post-MI patients with preserved LVEF, with conclusive evidence of futility, whereas therapy was associated with reduced MACE in those with...
Relevance: Meta-analysis of beta-blockers after myocardial infarction across ejection fraction strata. Carvedilol (beta-blocker) is in the profile formulary and heart failure is a core research interest. While the adult post-MI population differs from profile diagnoses, findings on beta-blocker effects in heart failure inform pediatric practice.
PMID: 42310876European journal of clinical investigation(Journal Article) Literature
Baseline Ejection Fraction as a Modifier of Beta-Blocker Therapeutic Effects in Post-Acute Coronary Syndrome Patients With Non-Reduced Ejection Fraction: A Systematic Review and Meta-Analysis.
Baseline Ejection Fraction as a Modifier of Beta-Blocker Therapeutic Effects in Post-Acute Coronary Syndrome Patients With Non-Reduced Ejection Fraction: A Systematic Review and Meta-Analysis.: New evidence identified. See linked sources for details.
Future larger RCTs are needed to clarify the role of beta-blockers in this borderline population.
Relevance: Systematic review of beta-blocker efficacy in post-ACS patients with preserved ejection fraction. Carvedilol (a beta-blocker) is in the profile formulary. While the specific population (adult ACS survivors) differs from profile diagnoses, beta-blocker effects on heart failure and cardiac outcomes are directly relevant to understanding profile drug use.
PMID: 42311050Cardiovascular therapeutics(Journal Article) Literature
Diuretic Intensity Score and Mortality in Hospitalized Heart Failure Patients: A Multicenter Propensity-Matched Analysis.
Diuretic Intensity Score and Mortality in Hospitalized Heart Failure Patients: A Multicenter Propensity-Matched Analysis.: New evidence identified. See linked sources for details.
Given the observational design, these findings should be regarded as hypothesis-generating associations rather than evidence of a causal benefit and require confirmation in prospective randomized...
Relevance: Meta-analysis of diuretic intensity and mortality in hospitalized heart failure patients. While furosemide (a diuretic) is in the profile formulary and heart failure is a key research interest, this study is in adult populations. Findings about diuretic dosing in heart failure are relevant to pediatric practice but the evidence base is adult-derived.
PMID: 42317053Clinical cardiology(Journal Article) Literature
Circulating nitric oxide pathway metabolites in heart failure with preserved ejection fraction: a sex-stratified cross-sectional analysis.
Circulating nitric oxide pathway metabolites in heart failure with preserved ejection fraction: a sex-stratified cross-sectional analysis.: New evidence identified. See linked sources for details.
ClinicalTrials.gov, TRN: NCT02078947.
Relevance: Cross-sectional analysis of nitric oxide metabolites in heart failure with preserved ejection fraction patients. Heart failure is a core research interest and relates to overall cardiac dysfunction management. While not disease-specific to profile diagnoses, understanding HFpEF pathophysiology is relevant to heart failure research in complex pediatric cardiac disease.
PMID: 42298662Biology of sex differences(Journal Article)