Literature
A Comparative Study to Evaluate the Pre and Post-Operative Electrocardiographic and Echocardiographic Changes in Children with Tetralogy of Fallot Undergoing Modified Blalock-Taussig-Thomas Shunt Surgery.
Signal observed in 35 children with tetralogy of Fallot undergoing modified Blalock-Taussig-Thomas shunt surgery showing measurable cardiac remodeling within 6 hours post-operatively. Evidence suggests improved pulmonary blood flow correlates with specific ECG changes including reduced P axis (62.05 to 54.94 degrees) and QRS axis (139.88 to 107.68 degrees), alongside increased left atrial reservoir volume (5.42 to 10.44 mL) and left ventricular end-diastolic volume. Worth noting that these early post-operative changes in hemodynamics, blood gas parameters, ECG, and echocardiography appear consistent with enhanced cardiac filling following palliative intervention.
Changes observed in the hemodynamics, blood gas parameters, ECG, and TTE are consistent with improved pulmonary blood flow.
Relevance: Directly addresses tetralogy of Fallot (dx-tof) in pediatric patients undergoing surgical intervention (mBTTS). Discusses ECG and echocardiographic changes in TOF children, directly relevant to profile diagnosis and pediatric cardiology assessment.
PMID: 41979296Annals of cardiac anaesthesia(Journal Article) Literature
Signals of Drug-Related Retinal Fibrosis: Findings From a 20-Year Disproportionality Analysis of Global Spontaneous Reports.
Signal observed in FDA adverse event database analysis identifying sildenafil among 16 drugs associated with retinal fibrosis, though categorized as relatively lower risk compared to anti-neovascularization agents. Evidence suggests adolescents (0-17 years) face higher risk when using certain drug classes, with off-label use increasing retinal fibrosis risk across identified medications. Worth noting this safety signal for sildenafil in the context of pediatric pulmonary hypertension management, where ophthalmologic monitoring considerations may be relevant.
Identifying specific drugs associated with RF is crucial for preventing drug-related RF and developing personalized monitoring strategies.
Relevance: Disproportionality analysis identifying sildenafil (profile drug) as associated with retinal fibrosis risk. Related to profile drug but in non-cardiac context; findings may inform understanding of sildenafil safety profile relevant to pediatric pulmonary hypertension management.
PMID: 41972870Translational vision science & technology(Journal Article)