Literature
Critical analysis of digitalis glycosides: declining use but increasing poison-center exposure cases for digitoxin.
Critical analysis of digitalis glycosides: declining use but increasing poison-center exposure cases for digitoxin.: New evidence identified. See linked sources for details.
This indicates discrepancies between prescribing trends and real-world exposure patterns and highlights the importance for patient selection and careful monitoring, especially in elderly patients.
Relevance: This is a critical analysis of digitalis glycosides (digoxin, digitoxin) prescribing trends and poison center data in Germany. Digoxin (drug-digoxin) is a profile formulary drug. The article examines long-term prescribing patterns, clinical utility, and safety of NaK-ATPase inhibitors in cardiovascular medicine. Although focused on adult populations, the findings directly inform pediatric practice where digoxin is used for heart failure and arrhythmia management.
PMID: 42334625European journal of clinical pharmacology(Journal Article) Literature
Standardised, telemonitored titration of guideline-directed medical therapy in heart failure is associated with faster optimisation and improved persistence compared to standard of care.
Standardised, telemonitored titration of guideline-directed medical therapy in heart failure is associated with faster optimisation and improved persistence compared to standard of care.: New evidence identified. See linked sources for details.
This approach may help address persistent GDMT implementation gaps.
Relevance: This study compares standardized, telemonitored titration of guideline-directed medical therapy (GDMT) with standard care in heart failure with reduced ejection fraction. The profile formulary includes multiple GDMT drugs (enalapril, carvedilol, furosemide). Heart failure is a major profile research interest. The article demonstrates improved outcomes with systematic GDMT optimization, directly applicable to pediatric heart failure management, particularly in single ventricle/Fontan populations.
PMID: 42331565Open heart(Journal Article) Literature
Prevalence and risk factors of potentially inappropriate medications at discharge in older adults with heart failure: A retrospective observational pharmacovigilance study.
Prevalence and risk factors of potentially inappropriate medications at discharge in older adults with heart failure: A retrospective observational pharmacovigilance study.: New evidence identified. See linked sources for details.
Common PIMs included furosemide, rabeprazole and rivaroxaban.
Relevance: This retrospective study identifies potentially inappropriate medications at discharge in older adults with chronic heart failure, with furosemide identified as a common PIM. Heart failure is a profile research interest, and furosemide (drug-furosemide) is a profile formulary drug. The study examines medication management in HF patients, relevant to understanding drug use patterns. Although focused on adult elderly populations, medication management principles apply to pediatric heart failure.
PMID: 42332485Medicine(Journal Article) Literature
Serum chloride trajectory and 28-day mortality in critically ill congestive heart failure: A retrospective multicenter cohort study deriving from MIMIC-IV and externally validated.
Serum chloride trajectory and 28-day mortality in critically ill congestive heart failure: A retrospective multicenter cohort study deriving from MIMIC-IV and externally validated.: New evidence identified. See linked sources for details.
These findings generate the hypothesis that careful management of progressive chloride rises may be beneficial, but this requires prospective testing in randomized trials.
Relevance: This retrospective multicenter cohort study examines serum chloride trajectories and mortality in critically ill congestive heart failure patients, using MIMIC-IV database. Heart failure is a profile research interest. The study provides evidence on pathophysiology and prognostic factors in CHF management. Although focused on adult ICU populations, findings on heart failure physiology and outcomes are relevant to pediatric heart failure management.
PMID: 42332467Medicine(Journal Article) Literature
Recurrent urticaria induced by aspirin in a post-stent patient: A case study and literature review.
Recurrent urticaria induced by aspirin in a post-stent patient: A case study and literature review.: New evidence identified. See linked sources for details.
Postdischarge follow-up confirmed sustained remission, highlighting the importance of collaborative care in managing drug-induced urticaria and maintaining cardiovascular safety.
Relevance: This case report describes aspirin-induced urticaria in a post-stent coronary heart disease patient (adult). Aspirin is a profile drug (drug-aspirin), and the article addresses adverse drug reactions and antiplatelet therapy management. While the focus is adult cardiology, findings about aspirin adverse effects and drug management strategies are relevant to pediatric cardiology practice where aspirin is used (e.g., Kawasaki disease, post-intervention antiplatelet therapy).
PMID: 42333511The Journal of international medical research(Journal Article) Literature
From China's Multicenter Prospective Cohort: Right Ventricular Afterload and Prognosis in Hospitalized Patients with Acute Exacerbation of COPD.
From China's Multicenter Prospective Cohort: Right Ventricular Afterload and Prognosis in Hospitalized Patients with Acute Exacerbation of COPD.: New evidence identified. See linked sources for details.
Early detection of these three risk factors could play a role in stratifying high-risk patients, guiding clinical decision-making, and improving patient outcomes in AECOPD.
Relevance: This prospective cohort study examines right ventricular afterload and pulmonary hypertension in acute COPD exacerbation patients. While it addresses pulmonary hypertension (a profile research interest) and RV function, the focus is on adult COPD populations, not pediatric cardiac conditions. The study is related to pulmonary hypertension management but not directly relevant to profile diagnoses or pediatric cardiology.
PMID: 42333376International journal of chronic obstructive pulmonary disease(Journal Article) Literature
[Clinical and functional characteristics of patients with interstitial lung disease and pulmonary hypertension from a specialized lung disease center in Buenos Aires].
[Clinical and functional characteristics of patients with interstitial lung disease and pulmonary hypertension from a specialized lung disease center in Buenos Aires].: New evidence identified. See linked sources for details.
Further studies are needed to define more effective therapeutic strategies.
Relevance: This retrospective observational study characterizes pulmonary hypertension associated with interstitial lung disease in adult patients. While pulmonary hypertension is a profile research interest, the focus is on ILD-associated PH in adults, and the study mentions phosphodiesterase-5 inhibitors (not sildenafil specifically). The connection to profile is through pulmonary hypertension interest but not through pediatric cardiology diagnoses or primary drug applications.
PMID: 42330386Medicina(Journal Article)