Literature
Successful treatment for collagen vascular disease-related respiratory failure with inhaled nitric oxide as a bridging therapy:A case report.
Signal observed of inhaled nitric oxide serving as bridging therapy in severe respiratory failure from collagen vascular disease. Evidence suggests iNO at 10 ppm rapidly improved PaO2/FIO2 ratio from <80, allowing time for immunosuppressive interventions without requiring ECMO. Worth noting the temporal association between iNO initiation and oxygenation improvement, suggesting pulmonary vascular dysfunction as a major contributor to hypoxemia in this autoimmune respiratory failure case.
73 : 270-273, February, 2026.
Relevance: Case demonstrates inhaled nitric oxide use for pulmonary vascular dysfunction, which relates to pulmonary hypertension research interest, though in adult autoimmune disease rather than pediatric cardiac context