Literature
Multidisciplinary introduction of peritoneal dialysis enabling ICU liberation and home-based care in Ebstein's anomaly with refractory ascites and CKD: a case report.
Signal observed in adult patient with Ebstein's anomaly-related right heart failure, where peritoneal dialysis enabled hemodynamic stabilization and ICU liberation when conventional hemodialysis was contraindicated. Evidence suggests peritoneal dialysis may offer advantages in hepato-cardio-renal syndrome by providing slow continuous ultrafiltration while preserving hemodynamic stability. Worth noting the multidisciplinary approach required for successful implementation in vasopressor-dependent shock.
Broader recognition of PD's role in such settings may help expand therapeutic options for patients who are otherwise considered unsuitable for conventional RRT in the...
Relevance: Case report of Ebstein's anomaly (a congenital right heart lesion related to profile diagnoses) with refractory ascites, CKD, and right heart failure, managed with peritoneal dialysis. Directly relevant to pediatric congenital heart disease and heart failure management, though not focusing on profile drugs.
PMID: 41944929CEN case reports(Journal Article) Literature
Sildenafil for bronchopulmonary dysplasia-associated pulmonary hypertension: A systematic search and narrative synthesis.
Evidence suggests limited high-quality data supporting sildenafil use for bronchopulmonary dysplasia-associated pulmonary hypertension, with no randomized controlled trials meeting systematic review criteria. Signal observed that echocardiographic improvement occurred in 47-77% of treated patients across nine observational studies, though mortality rates remained substantial at 13-35%. Worth noting the identified research gap requiring randomized controlled trials to establish efficacy and safety profiles.
More research, particularly randomized controlled trials, on the efficacy and safety of sildenafil treatment for preterm BPD-PH infants is needed.
Relevance: Systematic review of sildenafil for bronchopulmonary dysplasia-associated pulmonary hypertension in preterm infants. Directly addresses sildenafil (profile drug) for pulmonary hypertension (profile research interest) in a pediatric population, though not specifically the profile diagnoses.
PMID: 41943894Pediatrics international : official journal of the Japan Pediatric Society(Journal Article) Literature
Switch-back Ross, Bentall/Konno and valve-sparing root replacement: three cutting-edge solutions to complex left ventricular outflow tract obstruction post arterial switch in Taussig-Bing anomaly.
Signal observed that multiple surgical approaches including switch-back Ross, Bentall/Konno, and valve-sparing neo-aortic root replacement provide effective management for multi-level left ventricular outflow tract pathology following arterial switch in Taussig-Bing anomaly. Evidence suggests these techniques offer excellent relief of complex post-surgical complications in this TGA variant.
In Taussig-Bing anomaly, switch-back Ross, Bentall/Konno, and valve-sparing neo-aortic root replacement provide excellent relief of multi-level left ventricular outflow tract pathology post-arterial switch.
Relevance: Addresses Taussig-Bing anomaly (a variant of TGA) with surgical solutions for left ventricular outflow tract obstruction post-arterial switch. Directly relevant to profile diagnosis of TGA in pediatric cardiology, though focuses on surgical rather than medical management.
PMID: 41944533Multimedia manual of cardiothoracic surgery : MMCTS(Journal Article) Literature
Comparing TA-TAVR and SAVR in severe aortic regurgitation: outcomes and valve haemodynamics.
Evidence suggests comparable 2-year mortality and clinical outcomes between transapical transcatheter aortic valve replacement and surgical aortic valve replacement for severe aortic regurgitation. Signal observed that transcatheter approach provided superior valve hemodynamics while surgical approach achieved greater left ventricular dimensional regression. Worth noting the effectiveness of transcatheter intervention particularly in high-risk patients with significant left ventricular function improvement.
TAVR provided superior valve haemodynamics and was an effective treatment that significantly improved LV function, especially in high-risk patients.
Relevance: Comparison of transcatheter aortic valve replacement versus surgical replacement for severe aortic regurgitation. Relevant to adult valvular disease and aortic pathology management; findings may inform pediatric approaches to aortic disease, though not directly about profile diagnoses.
PMID: 41871886Open heart(Journal Article)