Literature
Quantification of pulmonary arterial pressure with 4D flow cardiac MRI velocity mapping in patients with suspected pulmonary hypertension: Comparison with right heart catheterization.
Signal observed that accelerated 4D flow MRI can non-invasively estimate pulmonary arterial pressures using hemodynamic parameters including mean helicity in the right ventricle and maximum cross-sectional pulmonary artery area. Evidence suggests strong correlation with right heart catheterization measurements (R² = 0.69 for mean PAP, R² = 0.80 for systolic PAP) with minimal bias in 32 patients with suspected pulmonary hypertension. Worth noting this technique could potentially reduce the need for invasive catheterization in monitoring pulmonary hypertension progression.
Therefore, this short-duration sequence could become a useful diagnostic and follow-up exam for patients with pulmonary hypertension.
Relevance: Addresses pulmonary hypertension assessment methods relevant to research interests and applicable to patients with complex congenital heart disease including single ventricle physiology.
PMID: 42024678PloS one(Journal Article) Literature
Restrictive filling pattern of transmitral inflow in acute decompensated heart failure with preserved ejection fraction: insights from the KCHF registry.
Evidence suggests that restrictive filling pattern (E/A ratio ≥2) occurs in 17.3% of HFpEF patients and is associated with increased heart failure rehospitalization risk (HR=1.58) but not mortality. Signal observed that patients with restrictive patterns had higher prevalence of atrial fibrillation, supranormal ejection fraction >65%, and elevated brain natriuretic peptide levels at discharge. Worth noting the differential impact on hospitalization versus survival outcomes in this large registry of 830 HFpEF patients.
A restrictive filling pattern of transmitral inflow was associated with an increased risk for HF hospitalisation, but not for all-cause death, in patients with acute...
Relevance: Provides insights into diastolic dysfunction patterns and outcomes relevant to heart failure research interest and applicable to understanding restrictive physiology in complex congenital heart disease.
PMID: 41997617Open heart(Journal Article) Literature
Effect of Once-Daily Macitentan 75 mg on the Pharmacokinetics of Sildenafil, Riociguat, or Rosuvastatin in Healthy Male Participants.
Evidence suggests no clinically relevant pharmacokinetic interactions between macitentan 75 mg and sildenafil, riociguat, or rosuvastatin in healthy adults, with geometric mean ratios and confidence intervals indicating preserved drug exposures. Signal observed that co-administration was generally well tolerated across all substrate combinations. Worth noting these findings support concurrent use of macitentan with common pulmonary arterial hypertension therapies without dose adjustments.
Due to the lack of clinically relevant drug-drug pharmacokinetic interactions, no dose adjustment is deemed necessary when co-administering once-daily macitentan 75 mg with BCRP or...
Relevance: Directly relevant to sildenafil use in practice formulary and pulmonary hypertension research interest, providing safety data for potential combination therapies in PAH management.
PMID: 42023995Journal of clinical pharmacology(Journal Article)