Literature
Dual Antiplatelet Therapy and Immediate Intensive Statin in Mild Ischemic Stroke: A Randomized Trial.
Dual Antiplatelet Therapy and Immediate Intensive Statin in Mild Ischemic Stroke: A Randomized Trial.: New evidence identified. See linked sources for details.
This study provides Class I evidence that in patients with mild ischemic stroke or TIA of presumed atherosclerotic cause, the combination of clopidogrel-aspirin plus delayed...
Relevance: This randomized trial examines dual antiplatelet therapy (clopidogrel-aspirin) in acute ischemic stroke and TIA patients. While aspirin is in the profile formulary and antiplatelet therapy relates to anticoagulation/antithrombotic management, this is an adult cerebrovascular study without pediatric cardiology application. Adult evidence on antiplatelet agents is moderately relevant to informing pediatric practice.
PMID: 42348803Neurology(Journal Article) Literature
Association between PRECISE-DAPT score and clinical Outcomes: a subgroup analysis of the DAPT-TR registry.
Association between PRECISE-DAPT score and clinical Outcomes: a subgroup analysis of the DAPT-TR registry.: New evidence identified. See linked sources for details.
These findings suggest that the PRECISE-DAPT score may serve as a multidimensional prognostic tool beyond bleeding risk stratification.
Relevance: This study evaluates the PRECISE-DAPT score in predicting bleeding and ischemic outcomes in adults on fixed-dose dual antiplatelet therapy (aspirin-clopidogrel) for coronary artery disease. Aspirin is in the profile formulary and anticoagulation/antiplatelet management relates to research interests. However, this is adult coronary disease without direct pediatric cardiology relevance.
PMID: 42348498Cardiovascular journal of Africa(Journal Article) Literature
Clinical spectrum, cardiac phenotypes, and outcomes of FHL1-related cardiomyopathies: a systematic review.
Clinical spectrum, cardiac phenotypes, and outcomes of FHL1-related cardiomyopathies: a systematic review.: New evidence identified. See linked sources for details.
Further research is needed to define prognostic markers and guide management.
Relevance: This systematic review characterizes FHL1-related cardiomyopathies with cardiac hypertrophy, arrhythmias, and conduction abnormalities in mostly male patients with median age 18 years. It addresses inherited cardiomyopathy with some pediatric cases, but does not directly address the profile diagnoses (HLHS, TOF, TGA, Fontan, Kawasaki) or specific formulary drugs.
PMID: 42304238BMC cardiovascular disorders(Journal Article) Literature
Outcomes of intraprocedural haemodynamic changes in patients undergoing mitral transcatheter edge-to-edge repair.
Outcomes of intraprocedural haemodynamic changes in patients undergoing mitral transcatheter edge-to-edge repair.: New evidence identified. See linked sources for details.
These findings underscore the importance of real-time haemodynamic assessment - especially in DMR - as a valuable procedural endpoint that may aid in optimising long-term...
Relevance: This study evaluates intraprocedural haemodynamic changes during mitral transcatheter edge-to-edge repair in adult patients, stratified by mitral regurgitation etiology. While addressing hemodynamic assessment and heart failure outcomes related to research interests, it concerns adult acquired valvular disease without pediatric congenital heart disease relevance.
PMID: 42290317EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology(Journal Article)